Depression, Anxiety, and Pubertal Timing: Current Research and Future Directions

Authors: Abigail G. Richburg (University of Michigan) , Dominic P. Kelly (University of Michigan) , Prof Pamela E. Davis-Kean (University of Michigan)

  • Depression, Anxiety, and Pubertal Timing: Current Research and Future Directions


    Depression, Anxiety, and Pubertal Timing: Current Research and Future Directions

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How to Cite:

Richburg, A. G., Kelly, D. P. & Davis-Kean, P. E., (2021) “Depression, Anxiety, and Pubertal Timing: Current Research and Future Directions”, University of Michigan Undergraduate Research Journal 15. doi:




Throughout recent decades, the rate of child and adolescent mental disorder diagnoses has risen significantly.1 A 2015 meta-analysis evaluating the prevalence of child and adolescent mental disorders in 27 countries from across the world estimated that 13.4% of children and adolescents are affected by mental disorders.2 A 2019 analysis of the National Survey of Children’s Health, a nationally representative sample from the United States, found that among children between the ages of 3–17 years, 3.2% and 7.1% had current depression and anxiety problems, respectively.3 Although these disorders can occur in children, they often first appear during adolescence, and adolescents are at heightened risk for diagnosis.48

Some theories suggest that adolescence may be a risky period for mental health disorders due to the varied effects of puberty on development. Although puberty itself is universal biological transition, the experience of puberty can differ dramatically between individuals depending on a complex interplay between multiple biological and social factors.9 One such factor is the effect of pubertal timing, defined here as the timing of the onset of puberty in relation to the timing of puberty for same-gender and same-age peers.5, 1011 Pubertal timing has been thought to affect the prevalence of depression and anxiety in adolescents.12 Given that we know that the age of onset of puberty is decreasing in both boys and girls worldwide,1315 understanding the effects of earlier pubertal timing on mental health outcomes is urgent.

Due to the important consequences of mental health disorders during adolescence and their downstream effects across the lifespan, greater comprehension is needed of the effects of pubertal timing on the development of depression and anxiety. Therefore, this review serves two purposes: first, to examine the existing research on the relationship between early and late pubertal timing on adolescent depression and anxiety; and second, to identify the unanswered questions and future directions required for this crucial line of research.

Mental Health Disorders and Adolescence

Globally, depression and anxiety are the most common mental health disorders in total.4, 1617 Depression affects many facets of a person’s life, including, but not limited to, daily functioning, mood, interests, appetite, cognition, and energy levels.1820 Likewise, anxiety has been shown to affect concentration, sleep, mood, and academic performance.2123 In general, depression is understood to be a collection of symptoms related to negative affect or an inability to feel pleasure,6, 18, 24 while anxiety is understood to be a state of negative emotional arousal with an intense focus on the future.23, 25 Theoretical work on depression and anxiety suggests that both disorders involve issues with downregulation of negative affect, but depression also involves issues with regulation of positive affect.7, 26 Approximately 6% and 4–7% of adults worldwide suffer from Major Depressive Disorder and Generalized Anxiety Disorder, respectively.19, 23 However, the two disorders frequently co-occur, and their symptoms often overlap.27 Furthermore, it is important to note that many people experience symptoms of depression and anxiety without being diagnosed with either condition.2021 Data suggest that female depression and anxiety rates are higher than male depression rates throughout the lifespan.2830

For adolescents, depression and anxiety are the most prevalent mental health disorders.3133 While mental health disorders can occur in children, they often first appear during adolescence.4, 6, 8 Depressive symptoms are related to a range of potential problem behaviors during adolescence, including drug and alcohol use,3435 risky sexual behaviors,3637 and suicidal behaviors.6, 3839 Likewise, anxiety may lead to harmful outcomes during adolescence, including worse academic achievement,22, 43 less peer acceptance,4445 more peer victimization,4446 and the development of depressive symptoms.47 Adolescent depression has also been shown to negatively impact downstream outcomes in adulthood, including impaired educational attainment,40 difficulty with interpersonal relationships,31,41 substance abuse,31 and mental health issues throughout the lifespan.31, 42 Similarly, adolescents who experience anxiety may experience downstream effects of their condition in adulthood, including decreased life satisfaction,48 poor family relationships,49 worse employment and income outcomes,50 and mental health issues.49, 51, 52

Mental Health Disorders and Pubertal Timing

Puberty marks a time of significant biological and social maturation9, 53 Biological maturation refers to hormonal changes, such as increased testosterone and estrogen, and resulting physical changes in the body, such as deepened voice for males and development of breasts in females.54 Social maturation refers to the fact that puberty marks a social milestone that is influenced by gender-specific societal views and expectations.55 The pubertal transition takes place throughout three to four years and involves complex interplay between these biological and social factors.9 Globally, data suggest that the onset of puberty is becoming earlier.13

The timing of a child’s pubertal onset is the result of biological and environmental factors and the interplay between them. Pubertal timing is a highly heritable trait;5759 an estimated 50–80% of the variation in pubertal timing is thought to be genetically determined.57 Some environmental factors thought to affect pubertal timing include chronic psychological stress, father absence, and parental conflict.55, 6061 Evidence indicates that children who live in low socioeconomic status (SES) households, particularly girls, experience earlier pubertal timing on average than their peers who live in middle or high SES households.55, 62, 63 Furthermore, pubertal timing seems to be influenced by childhood diet.6466 Various facets of childhood diets may differentially impact pubertal timing in boys and girls; for example, research has linked higher vegetable and lean protein consumption at the age of three to delayed breast development in girls and higher processed meat and refined grain consumption at the age of three to advanced testicular development in boys.65 Inversely, higher processed and high-fat food consumption tends to trigger the onset of puberty earlier, particularly for girls.66 Another cause is speculated to be exposure to endocrine-disrupting chemicals that are often found in plastics and other materials.14, 56

The consequences of offset pubertal timing are broad; for example, earlier pubertal timing has been associated with worsened body image and beliefs for girls,67 earlier and riskier adolescent sexual behavior for boys and girls,68 and adolescent substance use for boys and girls.69 Some of the most extensive work has been on the effects of pubertal timing on depression and anxiety, especially the differing effects of early and late pubertal timing.


Three commonly cited hypotheses attempt to explain the relationship between offset pubertal timing and increased risk of mental health disorders: the maturational disparity, social deviance, and gendered deviation hypotheses.5 The maturational disparity hypothesis posits that early pubertal timing is detrimental to both boys and girls due to the disparity between their advanced physical development and their relatively lagging cognitive and emotional development.5 Specifically, the mismatch between advanced development in the limbic system and gradual development in the prefrontal cortex may place early-developing adolescents at a higher risk for mental health disorders.5, 53, 55 The social deviance hypothesis postulates that offset pubertal timing, be it early or late, leads to an increased risk of mental health disorders.5 This may be due to the social consequences of being unlike one’s peers, such as the stress of feeling different or misunderstood.55 The gendered deviation hypothesis suggests that early-developing girls and late-developing boys are each at increased risk of mental health disorders.5 This elevated risk occurs at the intersection of within- and across-gender comparisons, as early maturing girls and late maturing boys constitute the most extreme ends of the entire peer group.5 While the maturational disparity hypothesis has received much empirical attention and support,5, 70 late pubertal timing is generally less understood and less studied,5, 53 and boys are generally underrepresented in puberty research,71 indicating the need for further research in order to better establish the veracity of these three theories.

Early pubertal timing.

Adolescents who experience the onset of puberty earlier than their same-gender and same-age peers have been shown to be at a higher risk for mental health disorders.5, 9, 70 This relationship has been observed in adolescent samples throughout the world.5, 72, 73 Both cross-sectional and longitudinal data support the negative correlation between pubertal timing and risk for mental health disorders.7475 Furthermore, these effects have been shown to persist into adulthood.11, 53

Early pubertal timing has been shown to be an especially significant risk factor for mental health disorders in females, an effect that has been consistently replicated.5, 53, 55 For example, a 2013 analysis of 3,648 girls from a U.K. birth cohort found a strong relationship between early menarche and increased depressive symptoms in early to mid-adolescence.76 In general, pubertal timing research has focused more on female adolescents, and the detrimental effects of early pubertal timing appear to be stronger for females.5, 55 Because females are two times more likely than males to develop mental health disorders during puberty,5, 77 the abundance of research regarding mental health in this population may be due to the relative prevalence of those disorders in this gender.

However, some studies have also demonstrated that early pubertal timing is also a strong risk factor for depression and anxiety in boys.5, 55, 78 A 2017 meta-analysis found that sex did not moderate the small but significant association found between early pubertal timing and mental health disorders, meaning that this relationship did not depend on sex.5 Some posit that although the magnitude of direct effects of pubertal timing on mental health disorders is similar for boys and girls, there is still reason to believe that the mechanisms that cause this effect may vary by sex.5 For example, psychosocial mechanisms may include the social and interpersonal skills required to navigate relationships during the pubertal transition. Boys and girls may differ in the extent to which they display such skills, but some researchers suggest that future research is needed to examine possible sex differences.5

Four mechanisms have commonly been proposed to explain the relationship between early pubertal timing and increased risk of mental health disorders: hormonal influence, maturation disparity, contextual amplification, and accentuation.70 First, the hormonal influence hypothesis proposes that the hormonal changes associated with puberty place early-developing adolescents at risk for poor mental health outcomes either due to greater sensitivity to pubertal hormones or because they are exposed to greater amounts of them.7980 Second, the maturation disparity hypothesis states that the relationship between early pubertal timing and mental health disorders is a result of the disparity between physical and psychosocial maturity in early-developing adolescents.70, 80 Third, the contextual amplification hypothesis states that the biological changes associated with puberty interact with stressful environments and amplify environmental stressors, such as peer pressure.70, 78 Finally, the accentuation hypothesis states that pre-existing emotional and behavioral issues, such as increased negative affect, become amplified due to the stress and uncertainty associated with early pubertal timing.5, 70, 74, 78

Late pubertal timing.

Compared to the findings on early pubertal timing, research findings related to late pubertal timing are more mixed.5, 53 Much of the literature seems to agree that late pubertal timing does not appear to make mental health disorders more likely for girls.5, 81 In fact, some studies have pointed to potential protective effects of late pubertal timing on mental health disorders for girls,5 and some studies of female adolescents have found a positive correlation between late pubertal timing and factors related to psychological functioning, such as academic achievement.53, 82

However, in line with the gendered deviation hypothesis, there is some research that suggests that late pubertal timing has a negative impact on boys.5, 10, 55, 8384 For example, a 2009 study found that depression was associated with early pubertal timing in girls and late pubertal timing in boys.83 Another 2010 study supported the gendered deviation hypothesis in its finding that under high peer stress, both early-developing girls and late-developing boys were at the highest risk for maladjustment.84 However, in contrast, a 2017 meta-analysis found no significant association between late pubertal timing and mental health disorders for either boys or girls.5 This disparity is potentially due to the relative lack of research examining late pubertal timing and mental health disorders. Generally, there is a much larger body of literature examining early pubertal timing as opposed to late pubertal timing,5 and given the lack of research that could be included in the aforementioned meta-analysis, more research is needed on the effects of late pubertal timing to be more confident of its effects.


Pubertal timing can be measured using a wide variety of methodologies, which can be split into two categories: one, concerning the timing of milestones of puberty, or two, using self- or parent-reports of pubertal onset.

First, pubertal timing can be measured by determining the onset of certain events associated with pubertal status for an individual. Pubertal status refers to an adolescent’s stage of pubertal development, regardless of the onset of puberty.9, 11 Health providers or researchers typically conduct these assessments of pubertal status.85 While there is considerable variation in the methodologies used to assess pubertal status,54 the most commonly used method is the fivestage scales for the development of secondary sexual characteristics throughout puberty known as the Tanner stages.8688 Pubertal timing can therefore be indexed by standardizing the measurement of an indicator of pubertal status, e.g. age at menarche, and categorizing the standardized scores of an individual as early, on time, or late. However, there is not necessarily widespread agreement on either what the best milestone to measure pubertal timing is or where the category boundaries should be.54 Therefore, instead of using categories of onset to measure pubertal timing, some researchers use the residuals from regressing pubertal stage on age in order to conceptualize pubertal timing as a continuous measure in terms of pubertal status, but this method also suffers from the lack of agreement on norms.54 In particular, pubertal timing in boys suffers from a lack of consensus on methods.55 Some studies use self-report of age at spermarche, or the onset of sperm emission, as an analogous event to self-report of age at menarche, but researchers disagree concerning whether this is a reliable indicator.50, 60, 89 Some argue that the most valid indicator of pubertal onset in boys is testicular volume,54 but this measurement can be perceived as invasive.55

Second, subjective measures are also frequently used to measure pubertal timing, such as self-reports and parent reports.54, 85 These measures are similar to the objective measures discussed above, but they differ in that they are reported by adolescents or parents as opposed to assessed by health providers or researchers.85 For example, the Pubertal Development Scale allows individuals to disclose the timing of certain pubertal milestones, such as menstruation in females, voice changes in males, and so on.54, 90 The retrospective report of puberty instrument is similar, but is designed to be reliably used even after the pubertal transition has ended.91 These methods also suffer from the same lack of consensus on the best milestones to use, particularly for boys.54


Pubertal timing results from the interactions between biological and environmental factors.9 Offset pubertal timing has been linked to increased risk of developing adolescent mental health disorders.5 Three generally acknowledged hypotheses offer explanations for this relationship: maturational disparity, social deviance, and gendered deviation70 Research examining the effects of offset pubertal timing on adolescent mental health disorders has yielded more consistent results for early as opposed to late pubertal timing.5 Many gaps remain in the literature, including, but not limited to, the effects of late pubertal timing and the most representative and predictive ways of measuring pubertal timing.

Future Directions

The body of research related to puberty has significantly increased in the past decade, particularly in regard to pubertal timing14, 85 However, much research has tended to focus on the effects of early pubertal timing in adolescent girls.5 There remains a need to examine the possible effects of late pubertal timing for both boys and girls, to parse pubertal timing and status, and to explore the pubertal experiences of understudied populations.

First, additional research is necessary to further examine the effects of late pubertal timing on adolescent depression and anxiety. Much of the existing pubertal timing research focuses on early as opposed to late pubertal timing, and there are fewer cross-sectional and longitudinal studies on the effects of late pubertal timing on adolescent depression and anxiety.5 The lack of research related to late pubertal timing may be in part due to the widespread popularity of the aforementioned maturational disparity hypothesis, which only focuses on the detrimental effects of early pubertal timing on adolescent mental health.5,70 Widespread acceptance of this idea may discourage research related to late pubertal timing. The lack of research on the effects of late pubertal timing on adolescent depression and anxiety makes it difficult to understand the extent to which this may or may not be a risk factor.

Second, more research is needed on the complex interplay between pubertal timing and pubertal status. Relatively few studies have directly compared pubertal timing and pubertal status.11 One such study found an association between early pubertal timing and depressive symptoms in girls at age 14, but not at ages 17 or 19,92 indicating that early-developing girls were more likely to develop depressive symptoms earlier on in the pubertal transition. Because females who experienced early pubertal timing will also be at a more advanced pubertal stage at the age of 14, and research has demonstrated an association between advanced pubertal stage in females and depressive symptoms, status in this example therefore may be the more important contributing factor to these depressive symptoms.11 While it is difficult to parse pubertal timing and status,54 such research is needed in order to determine the unique effects of each aspect of puberty on adolescent mental health disorders. Although a large-scale meta-analysis exists on the relationship between pubertal timing and adolescent mental health disorders,5 no such meta-analysis on the effects of pubertal status exists. Such a comprehensive review may be illuminating, as some research suggests that progression through pubertal stages is a more reliable indicator than pubertal timing of depression in girls.9, 93

Finally, further research is needed to evaluate the pubertal experiences of traditionally less studied groups, particularly adolescent boys, low-SES adolescents, racial and ethnic minorities, and LGBTQ+ adolescents.

Adolescent boys:

Adolescent boys are greatly underrepresented in puberty research.71 Some have speculated that the gender disparity in research may be related to the difficulty and uncertainty surrounding the measurement of pubertal timing in boys.55 There is less consensus on pubertal timing measures for boys than for girls.54 Furthermore, given that many of the mainstream pubertal timing theories reference gender differences (i.e. the maturational disparity hypothesis and the gendered deviation hypothesis), more research is needed to further examine these hypotheses.

Socioeconomic status:

Low-SES adolescents are also understudied in puberty research.85 Low-SES females often experience puberty earlier than their higher-SES peers.55, 6263 Menarche is thought to be related to nutrition and increased body fat,94 and low-SES girls are at increased risk for obesity due to decreased access to healthy foods.62, 95 Therefore, more research is needed to better understand the pubertal and mental health experiences of this at-risk population.

Racial and ethnic minorities:

In addition, racial and ethnic minorities are also understudied in puberty research.85, 96 Given that early pubertal timing is more frequently seen in minority groups such as African American and Latino adolescents,85, 97 more research is needed to better understand the pubertal experiences of racial and ethnic minorities.


Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) adolescents are also underrepresented in puberty research.96, 98 Given that LGBTQ+ adolescents often experience emotional distress as a result of peer discrimination and coming out,99100 an increased focus on this population may illuminate the unique experiences of puberty of LGBTQ+ adolescents. In particular, transgender adolescents may have particularly unique experiences with mental health disorders during puberty due to emotional distress resulting from physical development that conflicts with their gender identity.98, 101


Adolescent mental health disorders, specifically depression and anxiety, are a prevalent issue in psychology and society. Puberty involves a myriad of complex process, including pubertal timing, which have been shown to be related to increased risk for adolescent depression and anxiety. This review examined the existing evidence for the differential impacts of early and late pubertal timing on adolescent depression and anxiety. This discussion is especially urgent, as pubertal timing is decreasing globally among boys and girls. While stronger evidence exists implicating early pubertal timing in adolescent depression and anxiety, particularly for girls, more research is needed to clarify the mixed findings regarding late pubertal timing. Future pubertal timing research might want to focus on further exploring the potential effects of late pubertal timing on adolescent depression and anxiety, parsing pubertal status and timing, and diversifying samples to better understand the pubertal experiences of understudied groups, such as adolescent boys, low-SES adolescents, racial and ethnic minorities, and LGBTQ+ adolescents.


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